Endocrine Abstracts

Background: Optimal glucose management in older people is currently unclear. Recent guidelines recommend avoiding tight glycemic targets in elderly patients with comorbidities because intensive control is unlikely to achieve benefit and they are at higher risk of hypoglycaemia.Objective: To estimate the prevalence of potential overtreatment in older adults with diabetes mellitus and comorbidities.Design: Cross-sectional study.<...

Although, diabetes type I patients in Portugal have complete and free access to HbA1c management (via multiple daily injections) only a few percentage has been provided an insulin pump – priority is given to children and women in fertile age trying to get pregnant. By the end of 2014, 1.150 insulin pumps had already been provided by the National Program of Insulin Pumps, but at least 3.000 patients with indication for insulin pump use were in waiting list. HbA1c pre-pump ...

Background: Poorer control of risk factors for cardiovascular disease (cvd) has been reported in diabetic women compared with men.Objective: To investigate whether control of diabetes and risk factors for cvd differ between sexes in a cohort of diabetic patients monitored at an outpatient endocrinology clinic from 2004 till 2014.Design: Observational, retrospective cohort study.Patients and methods: A cohort ...

Introduction: Multiple Endocrine Neoplasia type 1 is an underdiagnosed autosomal dominant disorder, with inter and intrafamilial variability without a genotype-phenotype correlation.Case report: A young female (born in 1986) presented with galactorrhea and secondary amenorrhea in 2002, and investigation revealed a prolactinoma. Her brother (born in 1982) presenting gynecomastia and erectile dysfunction at age 21, was also diagnosed with prolactinoma. The...

Introduction: Hyperprolactinemia has been associated with several metabolic abnormalities both in glucose homeostasis, insulin sensitivity, and in lipid profile. Moreover, it has also been reported that many of them seem to improve after normalizing serum prolactin (PRL) concentrations.Objective: To study serum glucose, cholesterol and triglyceride in men with prolactinoma before and after chronic treatment with cabergoline.Patient...

Objective: To assess clinical outcome after pituitary surgery in patients nonfunctioning pituitary adenomas (NFPA) surgically treated in the past 3 decades in three tertiary referral hospitals.Methods: A multicenter retrospective study on clinical and pathological characteristics, treatment patterns, and outcome in patients with NFPA periodically followed up in specialized neuroendocrinology units who underwent surgery in the period 1982–2015 was pe...

The known functions of the thyroid hormones in the liver have expanded from their well-known roles in regulating metabolism to also participate in liver regeneration, senescence and hepatocarcinogenesis. The transcription factors STAT3 and NF-κB play a key role in liver homeostasis, in the response to infection and inflammation and in hepatocarcinoma development. Interleukin 6 (IL-6) and Tumour Necrosis α (TNFα) are the best-known cytokines responsible for hepat...

Introduction: Adequate iodine intake is important in pregnant women.Objective: To determinate iodine status and thyroid volumen (TV) in healthy pregnant women from Navarra (Spain), and to evaluate possible influence of diet.Methods: A cross-sectional study of 144 women in the first trimester of pregnancy (single pregnancies) was carried during 2014. We measured thyroid-stimulating hormone (TSH), free thyroxine (fT4) and antithyroid...

Objective: To compare the results of immunohistochemistry (IHC) and DNA sequencing in detection of BRAF V600E mutation in papillary thyroid carcinomas (PTC). BRAF V600E mutation is the most common genetic alteration in papillary thyroid carcinomas and is associated with worse prognosis. Direct sequencing is usually performed, but less expensive immunohistochemistry can be used instead.Methods: Study was performed in 54 consecutive PTCs during 2014–2...

Introduction: Adult nesidioblastosis is a rare entity that has motivated the publication of several case reports, but long-term outcomes are rarely described. Distal or sub-total pancreatectomy is indicated in cases of severe symptoms or lack of response to medical treatment. We report the case of a patient with persistent nesidioblastosis after pancreatectomy keeping under medical treatment for 24 years.Clinical case: Woman currently with 81-years old, ...